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Clinical Efficacy

DURATION-5: 24-week Clinical Trial Results

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Once-weekly BYDUREON is proven to provide powerful A1C reductions with the additional benefit of weight loss at 24 weeks. Learn more about how BYDUREON impacted A1C and weight in the DURATION-5 clinical trial below.

BYDUREON is not indicated for the management of obesity, and weight change was a secondary endpoint in clinical trials.


Study Design

DURATION-5: 24-week, randomized, open-label, active-comparator trial in which adults with type 2 diabetes received BYDUREON (2 mg QW) or BYETTA (5 mcg BID for 4 weeks, followed by 10 mcg BID) in addition to ongoing treatment with diet and exercise alone or with oral agents (metformin, a sulfonylurea, a thiazolidinedione [TZD], or a combination of any 2 of these agents); N = 252, ITT; 58% male, 59% Caucasian, 31% Hispanic; aged 56 years (mean); diabetes duration of 7 years (mean).1


Only once-weekly BYDUREON…

Powerful A1C Reductions of 1.6%*

Mean change in A1C from BL at 24 weeks
Mean change in A1C from BL at 24 weeks
Mean change in A1C from BL at 24 weeks

ITT population.

Abbreviations: BL, mean baseline; ITT, intent to treat; LS, least squares.

P < .001 vs comparator.

*Versus BYETTA.


Only once-weekly BYDUREON…

Provided the Additional Benefit of Weight Loss of 5.1 lb

BYDUREON is not indicated for the management of obesity, and weight change was a secondary endpoint in clinical trials.

BYDUREON is not indicated for the management of obesity, and weight change was a secondary endpoint in clinical trials.

Mean weight loss from BL at 24 weeks
Mean weight loss from BL at 24 weeks
Mean weight loss from BL at 24 weeks

ITT population

Abbreviations: BL, mean baseline; ITT, intent to treat; LS, least squares.

Versus BYETTA.

Designed to be patient-friendly.

BYDUREON Pen

Designed to be patient-friendly.

BYDUREON Pen

Designed to be
patient-friendly.

BYDUREON Savings

Eligible patients may save on their prescription.

BYDUREON Savings

Eligible patients may save on their prescription.